Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 168, Issue 12, Pages 1266-1277Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.2011.10111704
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Funding
- ERT, Inc.
- Abbott
- Albany Molecular Research
- Alfresa
- Alkermes
- Amgen
- AstraZeneca
- Biodelivery Sciences International
- Biomarin
- Bristol-Myers Squibb
- Canam
- Cato Research
- Cephalon
- Cetero Research
- Covance
- CRI Worldwide
- Depomed
- Douglas Pharmaceuticals
- Eisai
- Euthymics
- Forest
- GlaxoSmithKline
- GW Pharma
- Human Genome Sciences
- i3 Research,
- ICON
- IntelGenx
- Intracellular Therapies
- Johnson Johnson
- Kendle Early Stage
- Lilly USA
- Lundbeck A/S
- Lundbeck USA
- Medlmmune
- Medtronic
- Merck
- Neurosearch
- Next Wave Pharmaceuticals
- Novartis
- Noven
- NovoNordisk
- Orexigen
- Otsuka
- Parexel
- Pfizer
- PGx Health
- Pharmaceutical Product Development, Inc.
- Psyadon
- QED
- Quintiles
- Reckitt Benckiser
- Roche
- Sanofi-Aventis
- Schering-Plough
- SCOPE international
- sepracor/Sunovion
- Shire
- Siena Biotech
- Supernus
- Synosia Therapeutics
- Takeda
- Theravance
- Upsher-Smith
- Valeant
- Vivus
- World Wide Clinical Trials
- Wyeth Research
- NIMH
- Guilford Press
- Eli Lilly
- Janssen
- Otsuko
- Rhodes Pharmaceutical
- National Institute on Drug Abuse
- NIMH [MH66750, MH66769, MH66762, MH66775, MH66778]
- American Foundation for Suicide Prevention
- National Institute on Alcohol Abuse and Alcoholism Developing Centers on Interventions for the Prevention of Suicide [5 P20 AA015630]
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Objective: Research on suicide prevention and interventions requires a standard method for assessing both suicidal ideation and behavior to identify those at risk and to track treatment response. The Columbia Suicide Severity Rating Scale (C-SSRS) was designed to quantify the severity of suicidal ideation and behavior. The authors examined the psychometric properties of the scale. Method: The C-SSRS's validity relative to other measures of suicidal ideation and behavior and the internal consistency of its intensity of ideation subscale were analyzed in three multisite studies: a treatment study of adolescent suicide attempters (N=124); a medication efficacy trial with depressed adolescents (N=312); and a study of adults presenting to an emergency department for psychiatric reasons (N=237). Results: The C-SSRS demonstrated good convergent and divergent validity with other multi-informant suicidal ideation and behavior scales and had high sensitivity and specificity for suicidal behavior classifications compared with another behavior scale and an independent suicide evaluation board. Both the ideation and behavior subscales were sensitive to change over time. The intensity of ideation subscale demonstrated moderate to strong internal consistency. In the adolescent suicide attempters study, worst-point lifetime suicidal ideation on the C-SSRS predicted suicide attempts during the study, whereas the Scale for Suicide Ideation did not. Participants with the two highest levels of ideation severity (intent or intent with plan) at baseline had higher odds for attempting suicide during the study. Conclusions: These findings suggest that the C-SSRS is suitable for assessment of suicidal ideation and behavior in clinical and research settings.
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