Journal
CELLULOSE
Volume 15, Issue 2, Pages 275-283Publisher
SPRINGER
DOI: 10.1007/s10570-007-9165-5
Keywords
cellulose; strontium; drug release; biomimetic apatite; polysaccharide; bioactivity
Ask authors/readers for more resources
Strontium has attained increasing interest in the treatment of osteoporosis due to its anabolic as well as antiresorptive activity. Knitted cellulose scaffolds with a porosity suitable to promote bone tissue ingrowth and vascularisation were doped with SrCO3. The in vitro bioactivity of the modified scaffolds was proven by formation of hydroxyapatite during exposure to simulated body fluid. The Sr-release kinetics during static exposure to simulated body fluid is dominated by an accelerated Sr-release in the initial state followed by a reduced release corresponding to a diffusion controlled rate. Microstructural analyses indicate that initially precipitated SrCO3 transforms to Sr (x) Ca1-x CO3 solid solutions that subsequently serve as a template for the precipitation of bone like carbonated hydroxyapatite under conditions simulating the inorganic part of the human blood plasma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available