Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 166, Issue 4, Pages 410-417Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.2008.08081239
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Funding
- National Heart, Lung, and Blood Institute [HL-76808]
- Lewis and Jean Sachs Charitable Lead Trust
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Depression is a risk factor for morbidity and mortality in patients with coronary heart disease, especially following acute coronary syndrome. Evidence from recent clinical trials suggests that treatment-resistant depression may be associated with a particularly high risk of mortality or cardiac morbidity in patients following acute coronary syndrome. This article reviews this evidence and considers possible explanations for this relationship. Directions for future research are also considered, with particular emphasis on efforts to elucidate the underlying mechanisms and to develop more efficacious treatments for depression in patients with coronary heart disease.
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