Journal
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Volume 305, Issue 12, Pages L893-L905Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00267.2013
Keywords
BPD; lung development; alveolarization; hypoxia; growth factor; oxidative stress
Categories
Funding
- von Behring-Rontgen Foundation [51-0031]
- University Medical Center Giessen and Marburg [62580935]
- Federal Ministry of Higher Education, Research and the Arts of the State of Hessen LOEWE Program
- German Center for Lung Research (DZL)
- German Research Foundation through Excellence Cluster 147 Cardio-Pulmonary System
- Max Planck Society
- [Mo 1789/1]
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In contrast to early lung development, a process exemplified by the branching of the developing airways, the later development of the immature lung remains very poorly understood. A key event in late lung development is secondary septation, in which secondary septa arise from primary septa, creating a greater number of alveoli of a smaller size, which dramatically expands the surface area over which gas exchange can take place. Secondary septation, together with architectural changes to the vascular structure of the lung that minimize the distance between the inspired air and the blood, are the objectives of late lung development. The process of late lung development is disturbed in bronchopulmonary dysplasia (BPD), a disease of prematurely born infants in which the structural development of the alveoli is blunted as a consequence of inflammation, volutrauma, and oxygen toxicity. This review aims to highlight notable recent developments in our understanding of late lung development and the pathogenesis of BPD.
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