Journal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 191, Issue 1, Pages 34-44Publisher
AMER THORACIC SOC
DOI: 10.1164/rccm.201405-0901PP
Keywords
respiratory syncytial virus; RSV; rhinovirus; RV; asthma
Categories
Funding
- National Institutes of Health [HL81420, K24 AI 077930, UL1 RR024975, U19AI 095227]
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A first step in primary disease prevention is identifying common, modifiable risk factors that contribute to a significant proportion of disease development. Infant respiratory viral infection and childhood asthma are the most common acute and chronic diseases of childhood, respectively. Common clinical features and links between these diseases have long been recognized, with early-life respiratory syncytial virus (RSV) and rhinovirus (RV) lower respiratory tract infections (LRTIs) being strongly associated with increased asthma risk. However, there has long been debate over the role of these respiratory viruses in asthma inception. In this article, we systematically review the evidence linking early-life RSV and RV LRTIs with asthma inception and whether they could therefore be targets for primary prevention efforts.
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