Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 303, Issue 1, Pages H19-H35Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00764.2011
Keywords
G protein signaling expression; G protein signaling localization; G protein signaling phosphorylation
Funding
- National Institutes of Health [R01-GM-85058, T32-HL-007237, T32-HD-009007]
- American Heart Association [10PRE4190120, 10PRE2630163]
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Kach J, Sethakorn N, Dulin NO. A finer tuning of G-protein signaling through regulated control of RGS proteins. Am J Physiol Heart Circ Physiol 303: H19-H35, 2012. First published April 27, 2012; doi: 10.1152/ajpheart.00764.2011.-Regulators of G-protein signaling (RGS) proteins are GTPase-activating proteins (GAP) for various G alpha subunits of heterotrimeric G proteins. Through this mechanism, RGS proteins regulate the magnitude and duration of G-protein-coupled receptor signaling and are often referred to as fine tuners of G-protein signaling. Increasing evidence suggests that RGS proteins themselves are regulated through multiple mechanisms, which may provide an even finer tuning of G-protein signaling and crosstalk between G-protein-coupled receptors and other signaling pathways. This review summarizes the current data on the control of RGS function through regulated expression, intracellular localization, and covalent modification of RGS proteins, as related to cell function and the pathogenesis of diseases.
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