Journal
JOURNAL OF ABNORMAL CHILD PSYCHOLOGY
Volume 36, Issue 4, Pages 591-599Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10802-007-9202-8
Keywords
autism; adaptive behavior; family history; Vineland adaptive behavior scales; broader autism phenotype
Categories
Funding
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NICHD NIH HHS [U19 HD035469-09, U19 HD035469, U19 HD035469-06, HD35469, P50 HD055748, U19 HD035469-10, U19 HD035469-08, P01 HD035469] Funding Source: Medline
- NIDCD NIH HHS [K23 DC006691, K23 DC006691-04] Funding Source: Medline
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Adaptive behavior in autism is highly variable and strongly related to prognosis. This study explored family history as a potential source of variability in adaptive behavior in autism. Participants included 77 individuals (mean age = 18) with average or better intellectual ability and autism. Parents completed the Family History Interview about the presence of broader autism phenotype symptoms and major psychiatric disorders in first degree relatives. Adaptive behavior was assessed via the Vineland Adaptive Behavior Scales (VABS). Based on family history variables, age, and intelligence quotient (IQ), 87% of participants were correctly classified as having impaired or average VABS scores. Family history of depression and shyness accounted for the most variance in VABS scores, and they had the greatest influence on VABS Socialization scores in particular. Possible underlying mechanisms include genetics, psychosocial factors, and social resources. This study provides initial evidence of the importance of family history to adaptive behavior in autism and has implications for genetics and treatment.
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