4.4 Article

Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid

Journal

RHEUMATOLOGY INTERNATIONAL
Volume 28, Issue 7, Pages 631-635

Publisher

SPRINGER HEIDELBERG
DOI: 10.1007/s00296-007-0489-0

Keywords

interleukin-6; inflammation; cannabinoid acid; macrophages; rheumatoid arthritis

Categories

Funding

  1. NIAID NIH HHS [AI1056362] Funding Source: Medline
  2. NIAMS NIH HHS [T32AR07572] Funding Source: Medline
  3. NIDA NIH HHS [DA3691] Funding Source: Medline

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Interleukin-6 (IL-6) is a multifunctional cytokine which contributes to inflammation and tissue injury in several diseases. Thus, inhibition of IL-6 production may be a useful strategy for treatment of patients with diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A synthetic nonpsychoactive cannabinoid, ajulemic acid (AjA), prevents joint damage in experimental arthritis. Results of experiments presented here indicate that addition of AjA (3-30 mu M) to human monocyte derived macrophages in vitro reduces steady state levels of IL-6 mRNA and the subsequent secretion of IL-6 from LPS stimulated cells. Although AjA binds to and activates PPAR gamma, its anti IL-6 effects are PPAR gamma independent. These studies provide evidence to support the view that AjA may prove to be an effective, safe antiinflammatory agent.

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