Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 295, Issue 6, Pages H2299-H2307Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00155.2008
Keywords
remodeling; hypertension; elastic lamellae; fenestrae; spontaneously hypertensive rats
Funding
- Comunidad Autonoma de Madrid [GRSAL0093-2004, UAMBio 0514-2006, SAF 2006/02376]
- Red Tematica de Investigacion Cardiovascular RECAVA [RD06/0014/0011]
- Fundacion Mutua Madrilena
- Canadian Institute of Health Research [PG-13920]
- Heart and Stroke Foundation of Ontario [NA-5435, NA-4381]
Ask authors/readers for more resources
Arribas SM, Briones AM, Bellingham C, Gonzalez MC, Salaices M, Liu K, Wang Y, Hinek A. Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodeling. Am J Physiol Heart Circ Physiol 295: H2299-H2307, 2008. First published October 10, 2008; doi: 10.1152/ajpheart.00155.2008. Elastin is a major component of conduit arteries and a key determinant of vascular viscoelastic properties. Aberrant organization of elastic lamellae has been reported in resistance vessels from spontaneously hypertensive rats (SHR) before the development of hypertension. Hence, we have characterized the content and organization of elastic lamellae in conduit vessels of neonatal SHR in detail, comparing the carotid arteries from 1-wk-old SHR with those from Wistar-Kyoto (WKY) and Sprague Dawley (SD) rats. The general structure and mechanics were studied by pressure myography, and the internal elastic lamina organization was determined by confocal microscopy. Cyanide bromideinsoluble elastin scaffolds were also prepared from 1-mo-old SHR and WKY aortas to assess their weight, amino acid composition, three-dimensional lamellar organization, and mechanical characteristics. Carotid arteries from 1-wk-old SHR exhibited narrower lumen and greater intrinsic stiffness than those from their WKY and SD counterparts. These aberrations were associated with heightened elastin content and with a striking reduction in the size of the fenestrae present in the elastic lamellae. The elastin scaffolds isolated from SHR aortas also exhibited increased relative weight and stiffness, as well as the presence of peculiar trabeculae inside the fenestra that reduced their size. We suggest that the excessive and aberrant elastin deposited in SHR vessels during perinatal development alters their mechanical properties. Such abnormalities are likely to compromise vessel expansion during a critical period of growth and, at later stages, they could compromise hemodynamic function and participate in the development of systemic hypertension.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available