Related references
Note: Only part of the references are listed.A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis
Paul J. Rutgeerts et al.
GUT (2013)
Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study
K. R. Herrlinger et al.
JOURNAL OF CROHNS & COLITIS (2013)
Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis
V. Valatas et al.
MUCOSAL IMMUNOLOGY (2013)
A Randomized Controlled Trial of the Efficacy and Safety of CCX282-B, an Orally-Administered Blocker of Chemokine Receptor CCR9, for Patients with Crohn's Disease
Satish Keshav et al.
PLOS ONE (2013)
The Membrane-Bound Mucin Muc1 Regulates T Helper 17-Cell Responses and Colitis in Mice
Atsushi Nishida et al.
GASTROENTEROLOGY (2012)
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects With Moderate to Severe Crohn's Disease
Stephan R. Targan et al.
GASTROENTEROLOGY (2012)
B Cells That Produce Immunoglobulin E Mediate Colitis in BALB/c Mice
Jennifer C. Hoving et al.
GASTROENTEROLOGY (2012)
Abatacept for Crohn's Disease and Ulcerative Colitis
William J. Sandborn et al.
GASTROENTEROLOGY (2012)
New therapies for inflammatory bowel disease: from the bench to the bedside
Silvio Danese
GUT (2012)
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
Wolfgang Hueber et al.
GUT (2012)
Why study animal models of IBD?
Warren Strober
INFLAMMATORY BOWEL DISEASES (2012)
Microbial and histopathologic considerations in the use of mouse models of inflammatory bowel diseases
Trenton R. Schoeb et al.
INFLAMMATORY BOWEL DISEASES (2012)
Toll-like receptor-7 ligand imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis
Satheesh K. Sainathan et al.
INFLAMMATORY BOWEL DISEASES (2012)
Exclusive antagonism of the α4β7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates
Eric R. Fedyk et al.
INFLAMMATORY BOWEL DISEASES (2012)
Vedolizumab for the treatment of active ulcerative colitis: A randomized controlled phase 2 dose-ranging study
Asit Parikh et al.
INFLAMMATORY BOWEL DISEASES (2012)
Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis
William J. Sandborn et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease
William J. Sandborn et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy
Gary Bloomgren et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Review article: defining remission in ulcerative colitis
S. P. L. Travis et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2011)
Efficacy of Biological Therapies in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis
Alexander C. Ford et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2011)
IL-10-Producing Regulatory B10 Cells Inhibit Intestinal Injury in a Mouse Model
Koichi Yanaba et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Eran Elinav et al.
CELL (2011)
Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases
Warren Strober et al.
GASTROENTEROLOGY (2011)
Colitis and Intestinal Inflammation in IL10(-/-) Mice Results From IL-13R alpha 2-Mediated Attenuation of IL-13 Activity
Mark S. Wilson et al.
GASTROENTEROLOGY (2011)
Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams et al.
GASTROENTEROLOGY (2011)
Suppression of inflammation in ulcerative colitis by interferon-β-1a is accompanied by inhibition of IL-13 production
Peter J. Mannon et al.
GUT (2011)
Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis
Keith Leiper et al.
GUT (2011)
The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: a randomised study
Severine Vermeire et al.
GUT (2011)
The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases
Rajita Pappu et al.
IMMUNOLOGY (2011)
Pharmacological Intervention Studies Using Mouse Models of the Inflammatory Bowel Diseases: Translating Preclinical Data into New Drug Therapies
Iurii Koboziev et al.
INFLAMMATORY BOWEL DISEASES (2011)
Autoimmunity and inflammation: murine models and translational studies
Samuel W. Hall et al.
MAMMALIAN GENOME (2011)
Intestinal homeostasis and its breakdown in inflammatory bowel disease
Kevin J. Maloy et al.
NATURE (2011)
Genetics and pathogenesis of inflammatory bowel disease
Bernard Khor et al.
NATURE (2011)
CCL25/CCR9 Interactions Regulate Large Intestinal Inflammation in a Murine Model of Acute Colitis
Marc-Andre Wurbel et al.
PLOS ONE (2011)
Localized Delivery of Interferon-β by Lactobacillus Exacerbates Experimental Colitis
Adelle P. McFarland et al.
PLOS ONE (2011)
Interferon-β exacerbates Th17-mediated inflammatory disease
Robert C. Axtell et al.
TRENDS IN IMMUNOLOGY (2011)
The NIrp3 inflammasome: contributions to intestinal homeostasis
Md Hasan Zaki et al.
TRENDS IN IMMUNOLOGY (2011)
Evaluation of Therapeutic Targets in Animal Models of Arthritis How Does It Relate to Rheumatoid Arthritis?
Lisette Bevaart et al.
ARTHRITIS AND RHEUMATISM (2010)
Gene modulation and immunoregulatory roles of Interferonγ
Banishree Saha et al.
CYTOKINE (2010)
Interleukin-11 Reduces TLR4-Induced Colitis in TLR2-Deficient Mice and Restores Intestinal STAT3 Signaling
Deanna L. Gibson et al.
GASTROENTEROLOGY (2010)
Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis
William J. Sandborn et al.
GUT (2010)
The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis
Md. Hasan Zaki et al.
IMMUNITY (2010)
Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases
Jeremy Dupaul-Chicoine et al.
IMMUNITY (2010)
Influences of Intestinal Bacteria in Human Inflammatory Bowel Disease
Rachel Vanderploeg et al.
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2010)
Case Series: Ulcerative Colitis, Multiple Sclerosis, and Interferonbeta la
S. Rodrigues et al.
INFLAMMATORY BOWEL DISEASES (2010)
Phase I, Double-blind, Randomized, Placebo-controlled, Dose-escalation Study of NI-0401 (a Fully Human Anti-CD3 Monoclonal Antibody) in Patients with Moderate to Severe Active Crohn's Disease
C. Janneke van der Woude et al.
INFLAMMATORY BOWEL DISEASES (2010)
Fontolizumab in Moderate to Severe Crohn's Disease: A Phase 2, Randomized, Double-blind, Placebo-controlled, Multiple-dose Study
Walter Reinisch et al.
INFLAMMATORY BOWEL DISEASES (2010)
Prospective Randomized Open-label Multicenter Phase I/II Dose Escalation Trial of Visilizumab (HuM291) in Severe Steroid-refractory Ulcerative Colitis
Daniel C. Baumgart et al.
INFLAMMATORY BOWEL DISEASES (2010)
Granulocyte-Macrophage Colony-Stimulating Factor Elicits Bone Marrow-Derived Cells that Promote Efficient Colonic Mucosal Healing
Eric Bernasconi et al.
INFLAMMATORY BOWEL DISEASES (2010)
4SC-101, a Novel Immunosuppressive Drug, Inhibits IL-17 and Attenuates Colitis in Two Murine Models of Inflammatory Bowel Disease
Leo R. Fitzpatrick et al.
INFLAMMATORY BOWEL DISEASES (2010)
Homing of Immune Cells: Role in Homeostasis and Intestinal Inflammation
Ailsa L. Hart et al.
INFLAMMATORY BOWEL DISEASES (2010)
β7 Integrin Deficiency Suppresses B Cell Homing and Attenuates Chronic Ileitis in SAMP1/YitFc Mice
Gezahegn Gorfu et al.
JOURNAL OF IMMUNOLOGY (2010)
Early-onset Crohn Disease Is Associated With Male Sex and a Polymorphism in the IL-6 Promoter
Keren Sagiv-Friedgut et al.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2010)
Characterization of CCX282-B, an Orally Bioavailable Antagonist of the CCR9 Chemokine Receptor, for Treatment of Inflammatory Bowel Disease
Matthew J. Walters et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin et al.
NATURE (2010)
Severe Ulcerative Colitis After Rituximab Therapy
Daniela S. Ardelean et al.
PEDIATRICS (2010)
Leveraging Human Genetics to Develop Future Therapeutic Strategies in Rheumatoid Arthritis
Robert M. Plenge et al.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2010)
Overview of the biology of type I interferons
George D. Kalliolias et al.
ARTHRITIS RESEARCH & THERAPY (2010)
Can Animal Models of Disease Reliably Inform Human Studies?
H. Bart van der Worp et al.
PLOS MEDICINE (2010)
Transient Cytokine-Induced Liver Injury Following Administration of the Humanized Anti-CD3 Antibody Visilizumab (HuM291) in Crohn's Disease
Daniel C. Baumgart et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2009)
Antibody to Tropomyosin Isoform 5 and Complement Induce the Lysis of Colonocytes in Ulcerative Colitis
Ellen C. Ebert et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2009)
Regulatory Lymphocytes and Intestinal Inflammation
Ana Izcue et al.
ANNUAL REVIEW OF IMMUNOLOGY (2009)
Interferon beta-1a for the maintenance of remission in patients with Crohn's disease: results of a phase II dose-finding study
Claudia Pena Rossi et al.
BMC GASTROENTEROLOGY (2009)
Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells
Wendy S. Garrett et al.
CANCER CELL (2009)
S1066 Oral Alpha-4 Integrin Inhibitor (AJM300) in Patients with Active Crohn's Disease — A Randomized, Double-Blind, Placebo-Controlled Trial
Masakazu Takazoe et al.
GASTROENTEROLOGY (2009)
Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Murine Ileitis and Progressive Ileal Crohn's Disease
Xiaonan Han et al.
GASTROENTEROLOGY (2009)
Steroid-sparing properties of sargramostim in patients with corticosteroid-dependent Crohn's disease: a randomised, double-blind, placebo-controlled, phase 2 study
J. F. Valentine et al.
GUT (2009)
Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis
C. Coquerelle et al.
GUT (2009)
Janus kinases in immune cell signaling
Kamran Ghoreschi et al.
IMMUNOLOGICAL REVIEWS (2009)
Alterations in Myeloid Dendritic Cell Innate Immune Responses in the Gαi2-deficient Mouse Model of Colitis
J. A. Pena et al.
INFLAMMATORY BOWEL DISEASES (2009)
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
Andrew M. Smith et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
A protective function for interleukin 17A in T cell-mediated intestinal inflammation
William O'Connor et al.
NATURE IMMUNOLOGY (2009)
MECHANISMS OF DISEASE Inflammatory Bowel Disease
Clara Abraham et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Efficient colonic mucosal wound repair requires Trem2 signaling
Hiroshi Seno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases
Manolis Pasparakis
NATURE REVIEWS IMMUNOLOGY (2009)
New insights into the regulation of T cells by γc family cytokines
Yrina Rochman et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Clinical trial:: a multicentre, randomized, double-blind, placebo-controlled, dose-finding, phase II study of subcutaneous interferon-β-1a in moderately active ulcerative colitis
C. Pena-Rossi et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2008)
Anti-adhesion molecule therapies in inflammatory bowel disease: Touch and go
Tommaso Stefanelli et al.
AUTOIMMUNITY REVIEWS (2008)
The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation
Yinghua Xu et al.
CELL RESEARCH (2008)
Treatment of Active Crohn's Disease With MLN0002, a Humanized Antibody to the α4β7 Integrin
Brian G. Feagan et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2008)
Vizilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways
Qi T. Yu et al.
CLINICAL IMMUNOLOGY (2008)
Mucosal T cell proliferation and apoptosis in inflammatory bowel disease
Andreas Sturm et al.
CURRENT DRUG TARGETS (2008)
Clinical course of ulcerative colitis
M. Cottone et al.
DIGESTIVE AND LIVER DISEASE (2008)
Role of β7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease
Maria Apostolaki et al.
GASTROENTEROLOGY (2008)
A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
William J. Sandborn et al.
GASTROENTEROLOGY (2008)
Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
Ana Izcue et al.
IMMUNITY (2008)
The interleukin-23 axis in intestinal inflammation
Philip P. Ahern et al.
IMMUNOLOGICAL REVIEWS (2008)
Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice
Robert A. Edwards et al.
INFLAMMATORY BOWEL DISEASES (2008)
Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis
Satheesh K. Sainathan et al.
INFLAMMATORY BOWEL DISEASES (2008)
Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease
Silvia Melgar et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2008)
Regulation of inflammatory responses by IL-17F
Xuexian O. Yang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Andre Franke et al.
NATURE GENETICS (2008)
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Jeffrey C. Barrett et al.
NATURE GENETICS (2008)
An antibiotic-responsive mouse model of fulminant ulcerative colitis
Silvia S. Kang et al.
PLOS MEDICINE (2008)
Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
M. Hegen et al.
ANNALS OF THE RHEUMATIC DISEASES (2008)
Successful treatment of steroid refractory active ulcerative colitis with natural interferon-β -: an open long-term trial
E. Musch et al.
ZEITSCHRIFT FUR GASTROENTEROLOGIE (2007)
A phase I study of visilizumab a humanized anti-CD3, monoclonal antibody, in severe steroid-refractory ulcerative colitis
Scott Plevy et al.
GASTROENTEROLOGY (2007)
Exacerbation of ulcerative colitis after rituximab salvage therapy
Martin Goetz et al.
INFLAMMATORY BOWEL DISEASES (2007)
Aberrant activation of integrin α4β7 suppresses lymphocyte migration to the gut
Eun Jeong Park et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
IL-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance
Jonas Mudter et al.
INFLAMMATORY BOWEL DISEASES (2007)
Natalizumab for the treatment of active Crohn's disease: Results of the ENCORE trial
Stephan R. Targan et al.
GASTROENTEROLOGY (2007)
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Arianna Nenci et al.
NATURE (2007)
A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease
Bruce Yacyshyn et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2007)
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
Richard H. Duerr et al.
SCIENCE (2006)
Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial
G. Van Assche et al.
GUT (2006)
Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice
R. Ito et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2006)
Interleukin-23 drives innate and T cell-mediated intestinal inflammation
Sophie Hue et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
Marika C. Kullberg et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Translation of research evidence from animals to humans
Daniel G. Hackam et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
K. Mitsuyama et al.
GUT (2006)
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
Holm H. Uhlig et al.
IMMUNITY (2006)
Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease
D. W. Hommes et al.
GUT (2006)
Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection
Maria Van der Sluis et al.
GASTROENTEROLOGY (2006)
A Phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
SJH Van Deventer et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2006)
Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease
TJ Creed et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2006)
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
D Yen et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Gut-associated lymphoid tissue-primed CD4+ T cells display CCR9-dependent and -independent homing to the small intesfine
H Stenstad et al.
BLOOD (2006)
New genes in inflammatory bowel disease: lessons for complex diseases?
DR Gaya et al.
LANCET (2006)
Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease
KR Herllinger et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)
Defective acute inflammation in Crohn's disease: a clinical investigation
DJB Marks et al.
LANCET (2006)
Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis
S Farkas et al.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2006)
A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease
Henri Braat et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2006)
Infliximab for induction and maintenance therapy for ulcerative colitis
P Rutgeerts et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
A function for interleukin 2 in Foxp3-expressing regulatory T cells
JD Fontenot et al.
NATURE IMMUNOLOGY (2005)
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition
MC Genovese et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
CO Elson et al.
IMMUNOLOGICAL REVIEWS (2005)
Impaired B cell responses to orally administered antigens in lamina propria but not Peyer's patches of Gαi2-deficient mice prior to colitis
L Öhman et al.
IMMUNOLOGY (2005)
Interferon-β-1a for the treatment of steroid-refractory ulcerative colitis:: A randomized, double-blind, placebo-controlled trial
E Musch et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2005)
Treatment with nomnitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis
AP Kohm et al.
JOURNAL OF IMMUNOLOGY (2005)
In vivo demonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1
K Matsuzaki et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2005)
Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
R Setoguchi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Increased lymphocyte trafficking to colonic microvessels is dependent on MAdCAM-1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis
K Teramoto et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2005)
Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation
G Bamias et al.
GASTROENTEROLOGY (2005)
L-Selectin, α4β1, and α4β7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine
J Rivera-Nieves et al.
JOURNAL OF IMMUNOLOGY (2005)
An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease
JR Korzenik et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2005)
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
KS Kobayashi et al.
SCIENCE (2005)
Regulatory CD4+ CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGε26 mice leading to the prevention of colitis
C Veltkamp et al.
GUT (2005)
Linkage to peroxisome proliferator-activated receptor-γ in SAMP1/YitFc mice and in human Crohn's disease
K Sugawara et al.
GASTROENTEROLOGY (2005)
Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-α
H Mitoma et al.
GASTROENTEROLOGY (2005)
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
H Ito et al.
GASTROENTEROLOGY (2004)
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
TS Olson et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
A Ogawa et al.
CLINICAL IMMUNOLOGY (2004)
CD4+CD25+ regulatory T cells cure murine colitis:: The role of IL-10, TGF-β, and CTLA4
HY Liu et al.
JOURNAL OF IMMUNOLOGY (2003)
TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
M Belghith et al.
NATURE MEDICINE (2003)
Interferon β-1a in ulcerative colitis:: a placebo controlled, randomised, dose escalating study
S Nikolaus et al.
GUT (2003)
Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice
H Takagi et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2003)
Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice
T Ishikura et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2003)
TNF-α neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis
M Marini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
TJ Creed et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2003)
Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease
JMH Van Den Brande et al.
GASTROENTEROLOGY (2003)
Evidence for the critical role of interleukin-12 but not interferon-γ in the pathogenesis of experimental colitis in mice
K Tozawa et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2003)
Therapeutic effect of anti-OX40L and anti-TNF-α MAbs in a murine model of chronic colitis
T Totsuka et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis
J Rivera-Nieves et al.
GASTROENTEROLOGY (2003)
B cell developmental requirement for the Gαi2 gene
H Dalwadi et al.
JOURNAL OF IMMUNOLOGY (2003)
A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis
G Van Assche et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2003)
CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms
KJ Maloy et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis
KJ Myers et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease
D Kontoyiannis et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
F Heller et al.
IMMUNITY (2002)
Homeostasis of peripheral CD4+ T cells:: IL-2Rα and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
ARM Almeida et al.
JOURNAL OF IMMUNOLOGY (2002)
The interaction properties of costimulatory molecules revisited
AV Collins et al.
IMMUNITY (2002)
Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease
BR Yacyshyn et al.
GUT (2002)
β7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis
BC Sydora et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2002)
Induction and maintenance of clinical remission by interferon-β in patients with steroid-refractory active ulcerative colitis -: an open long-term pilot trial
E Musch et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2002)
Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
PV Sivakumar et al.
GUT (2002)
Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon γ
H Tilg et al.
GUT (2002)
Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA
S Wirtz et al.
JOURNAL OF IMMUNOLOGY (2002)
Colorectal cancer in mice genetically deficient in the mucin Muc2
A Velcich et al.
SCIENCE (2002)
A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+CD4+T cells: Insights into the regulatory role of interleukin-6 on apoptosis
J Mudter et al.
PATHOBIOLOGY (2002)
Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice
RC Burns et al.
GASTROENTEROLOGY (2001)
Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α production in mice
T Ten Hove et al.
GASTROENTEROLOGY (2001)
Etanercept for active Crohn's disease: A randomized, double-blind, placebo-controlled trial
WJ Sandborn et al.
GASTROENTEROLOGY (2001)
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production
B Siegmund et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2001)
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease
T Kanai et al.
GASTROENTEROLOGY (2001)
B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis
ZJ Liu et al.
JOURNAL OF IMMUNOLOGY (2001)
Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice:: Cytokine requirements for the induction and maintenance of intestinal inflammation
MC Kullberg et al.
INFECTION AND IMMUNITY (2001)
Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease
JF Colombel et al.
GUT (2001)
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
JP Hugot et al.
NATURE (2001)
HuM291 (NUVION), a humanized Fc receptor-nonbinding antibody against CD3, anergizes peripheral blood T cells as partial agonist of the T cell receptor
LA Chau et al.
TRANSPLANTATION (2001)
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
MM Kosiewicz et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Cutting edge:: Typhlocolitis in NF-κB-deficient mice
SE Erdman et al.
JOURNAL OF IMMUNOLOGY (2001)
Role of P-selectin and intercellular adhesion molecule-1 in TNB-induced colitis in rats
N Yoshida et al.
DIGESTION (2001)
Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease
S Schreiber et al.
GASTROENTEROLOGY (2000)
Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease
RN Fedorak et al.
GASTROENTEROLOGY (2000)
IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-γ dependent manner
S Chikano et al.
GUT (2000)
The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system
KA Papadakis et al.
JOURNAL OF IMMUNOLOGY (2000)
VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice
A Soriano et al.
LABORATORY INVESTIGATION (2000)
Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice
EG Lee et al.
SCIENCE (2000)
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
L Steidler et al.
SCIENCE (2000)
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation
S Read et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
IL-6 is required for the development of Th1 cell-mediated murine colitis
M Yamamoto et al.
JOURNAL OF IMMUNOLOGY (2000)
Regulatory role of mature B cells in a murine model of inflammatory bowel disease
E Mizoguchi et al.
INTERNATIONAL IMMUNOLOGY (2000)
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo
R Atreya et al.
NATURE MEDICINE (2000)
Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
L Gorelik et al.
IMMUNITY (2000)
Intercellular adhesion molecule-1 (ICAM-1) deficiency protects mice against severe forms of experimentally induced colitis
F Bendjelloul et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2000)
Share Paper
