Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 5, Pages 349-361Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2294
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Funding
- NIDCR NIH HHS [P50 DE016191-04, P50 DE016191, P50-DE016191] Funding Source: Medline
- NIDDK NIH HHS [R01 DK074448-03, R01 DK074448, DK074448] Funding Source: Medline
- NIGMS NIH HHS [R01 GM038765, R37 GM038765, GM38765, R37 GM038765-21] Funding Source: Medline
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Active resolution of acute inflammation is a previously unrecognized interface between innate and adaptive immunity. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programmes that enable inflamed tissues to return to homeostasis. This Review presents new cellular and molecular mechanisms for the resolution of inflammation, revealing key roles for eicosanoids, such as lipoxins, and recently discovered families of endogenous chemical mediators, termed resolvins and protectins. These mediators have anti-inflammatory and pro-resolution properties, thereby protecting organs from collateral damage, stimulating the clearance of inflammatory debris and promoting mucosal antimicrobial defence.
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