4.7 Article

Non-Hodgkin lymphoma and obesity: A pooled analysis from the InterLymph consortium

Journal

INTERNATIONAL JOURNAL OF CANCER
Volume 122, Issue 9, Pages 2062-2070

Publisher

WILEY
DOI: 10.1002/ijc.23344

Keywords

non-Hodgkin lymphoma; lymphoma; body mass index weight; height; epidemiology

Categories

Funding

  1. Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
  2. Intramural NIH HHS [ZIA CP010170-13] Funding Source: Medline
  3. NCI NIH HHS [N01 PC065064, PC71105, 5R01 CA69269-02, N01 PC067009, PC67008, R01 CA069269, N01 PC067010, PC67009, CA50850, N01 PC067008, R01 CA051086, CA92153, R01 CA051086-03, R01 CA092153, N01 PC067009-025, PC65064, PC67010] Funding Source: Medline

Ask authors/readers for more resources

Nutritional status is known to alter immune function, a suspected risk factor for non-Hodgkin lymphoma (NHL). To investigate whether long-term over, or under, nutrition is associated with NHL, self-reported anthropometric data on weight and height from over 10,000 cases of NHL and 16,000 controls were pooled across 18 case-control studies identified through the International Lymphoma Epidemiology Consortium. Study-specific odds ratios (OR) were estimated using logistic regression and combined using a random-effects model. Severe obesity, defined as BMI of 40 kg m(-2) or more, was not associated with NHL overall (pooled OR = 1.00, 95% confidence interval (CI) 0.70-1.41) or the majority of NHL subtypes. An excess was however observed for diffuse large B-cell lymphoma (pooled OR = 1.80, 95% CI 1.24-2.62), although not all study-specific ORs were raised. Among the overweight (BMI 25-29.9 kg m(-2)) and obese (BMI 30-39.9 kg m(-2)), associations were elevated in some studies and decreased in others, while no association was observed among the underweight (BMI < 18.5 kg m(-2)). There was little suggestion of increasing ORs for NHL or its subtypes with every 5 kg m(-2) rise in BMI above 18.5 kg m(-2). BMI components height and weight were also examined, and the tallest men, but not women, were at marginally increased risk (pooled OR = 1.19, 95% CI 1.06-1.34). In summary, whilst we conclude that there is no evidence to support the hypothesis that obesity is a determinant of all types of NHL combined, the association between severe obesity and diffuse large B-cell lymphoma may warrant further investigation. (C) 2007 Wiley-Liss, Inc.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available