4.6 Review

The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling

Related references

Note: Only part of the references are listed.
Review Cell Biology

Flies, worms and the Free Radical Theory of ageing

David Clancy et al.

AGEING RESEARCH REVIEWS (2013)

Review Cell Biology

MicroRNAs linking inflamm-aging, cellular senescence and cancer

Fabiola Olivieri et al.

AGEING RESEARCH REVIEWS (2013)

Review Biochemistry & Molecular Biology

The Free Radical Theory of Aging Revisited: The Cell Signaling Disruption Theory of Aging

Jose Vina et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Signaling the mitochondrial unfolded protein response

Mark W. Pellegrino et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

Edward Owusu-Ansah et al.

Article Cell Biology

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

Elizabeth A. Schroeder et al.

CELL METABOLISM (2013)

Review Endocrinology & Metabolism

Inflamm-ageing

Elisa Cevenini et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2013)

Review Medicine, Research & Experimental

MicroRNAs in age-related diseases

Stefanie Dimmeler et al.

EMBO MOLECULAR MEDICINE (2013)

Article Geriatrics & Gerontology

Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders

Motoko Kawashima et al.

EXPERIMENTAL GERONTOLOGY (2013)

Review Biochemistry & Molecular Biology

MitomiRs delineating the intracellular localization of microRNAs at mitochondria

S. Bandiera et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Review Medicine, General & Internal

Sirtuins: the molecular basis of beneficial effects of physical activity

Bruna Pucci et al.

INTERNAL AND EMERGENCY MEDICINE (2013)

Review Medicine, Research & Experimental

The role of mitochondria in aging

Ana Bratic et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Endocrinology & Metabolism

The emerging role of the mitochondrial-derived peptide humanin in stress resistance

Kelvin Yen et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2013)

Article Cell Biology

Superoxide radicals have a protective role during H2O2 stress

Geoffrey W. Thorpe et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

Review Multidisciplinary Sciences

mTOR is a key modulator of ageing and age-related disease

Simon C. Johnson et al.

NATURE (2013)

Article Multidisciplinary Sciences

Mitonuclear protein imbalance as a conserved longevity mechanism

Riekelt H. Houtkooper et al.

NATURE (2013)

Article Multidisciplinary Sciences

Autophagosomes form at ER-mitochondria contact sites

Maho Hamasaki et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Kathrin Schmeisser et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Angie L. Bookout et al.

NATURE MEDICINE (2013)

Article Multidisciplinary Sciences

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Basil P. Hubbard et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

Sehyun Chae et al.

SCIENCE SIGNALING (2013)

Review Endocrinology & Metabolism

Humanin: a harbinger of mitochondrial-derived peptides?

Changhan Lee et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)

Article Biochemistry & Molecular Biology

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

Kazuhiko Higashida et al.

PLOS BIOLOGY (2013)

Article Endocrinology & Metabolism

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

Sebastian Schmeisser et al.

MOLECULAR METABOLISM (2013)

Review Biochemistry & Molecular Biology

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

Thomas A. Rando et al.

Article Cell Biology

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

Stacey Robida-Stubbs et al.

CELL METABOLISM (2012)

Article Biochemistry & Molecular Biology

Mitochondria and Organismal Longevity

Ara B. Hwang et al.

CURRENT GENOMICS (2012)

Review Biochemistry & Molecular Biology

Signal Transduction by Mitochondrial Oxidants

Toren Finkel

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

Julie A. Mattison et al.

NATURE (2012)

Review Cell Biology

Endoplasmic reticulum-mitochondria contacts: function of the junction

Ashley A. Rowland et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Review Cell Biology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Grahame Hardie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Cell Biology

Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice

Sarah Hempenstall et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2012)

Article Multidisciplinary Sciences

Tissue-Specific Responses of IGF-1/Insulin and mTOR Signaling in Calorie Restricted Rats

Naveen Sharma et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Superoxide dismutase is dispensable for normal animal lifespan

Jeremy Michael Van Raamsdonk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

Amrita M. Nargund et al.

SCIENCE (2012)

Review Cell Biology

Resveratrol as a calorie restriction mimetic: therapeutic implications

Jay H. Chung et al.

TRENDS IN CELL BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Epigenetic Control of Aging

Ursula Munoz-Najar et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Article Biochemistry & Molecular Biology

Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae

Joon-Seok Choi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Jenni Durieux et al.

Review Biochemistry & Molecular Biology

Autophagy and Aging

David C. Rubinsztein et al.

Editorial Material Cell Biology

A CRTCal Link between Energy and Life Span

Anne Brunet

CELL METABOLISM (2011)

Review Cell Biology

Crosstalk of reactive oxygen species and NF-kappa B signaling

Michael J. Morgan et al.

CELL RESEARCH (2011)

Article Neurosciences

Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview

Vincenzo Pizza et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2011)

Review Biochemistry & Molecular Biology

Exercise-induced oxidative stress in humans: Cause and consequences

Scott K. Powers et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Biochemistry & Molecular Biology

Extending life span by increasing oxidative stress

Michael Ristow et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Urology & Nephrology

miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes

Xue-Yuan Bai et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Article Biochemistry & Molecular Biology

Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways

Yun Chau Long et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Caloric restriction

John R. Speakman et al.

MOLECULAR ASPECTS OF MEDICINE (2011)

Review Biochemistry & Molecular Biology

Regulation of reactive oxygen species generation in cell signaling

Yun Soo Bae et al.

MOLECULES AND CELLS (2011)

Article Multidisciplinary Sciences

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

William Mair et al.

NATURE (2011)

Article Multidisciplinary Sciences

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Eric L. Greer et al.

NATURE (2011)

Review Cell Biology

mTOR: from growth signal integration to cancer, diabetes and ageing

Roberto Zoncu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

Review Medical Laboratory Technology

Sirt1's systemic protective roles and its promise as a target in antiaging medicine

Bor Luen Tang

TRANSLATIONAL RESEARCH (2011)

Review Cell Biology

Aging and disease: connections to sirtuins

Gizem Donmez et al.

AGING CELL (2010)

Review Pathology

Mammalian Sirtuins: Biological Insights and Disease Relevance

Marcia C. Haigis et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Review Geriatrics & Gerontology

Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage

Johannes Grillari et al.

EXPERIMENTAL GERONTOLOGY (2010)

Article Biochemistry & Molecular Biology

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Michelle Pacholec et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

Ru-Feng Wu et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Multidisciplinary Sciences

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

Evan W. Miller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

ATM Activation by Oxidative Stress

Zhi Guo et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

Wen Yang et al.

PLOS BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

Geoffrey Gloire et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Review Biochemistry & Molecular Biology

Is the oxidative stress theory of aging dead?

Viviana I. Perez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Article Biochemistry & Molecular Biology

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

Jeffrey M. Copeland et al.

CURRENT BIOLOGY (2009)

Review Biochemistry & Molecular Biology

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Carles Canto et al.

CURRENT OPINION IN LIPIDOLOGY (2009)

Article Geriatrics & Gerontology

Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice

Reyhan Westbrook et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)

Article Multidisciplinary Sciences

Histone H4 lysine 16 acetylation regulates cellular lifespan

Weiwei Dang et al.

NATURE (2009)

Article Multidisciplinary Sciences

Direct control of mitochondrial function by mTOR

Arvind Ramanathan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Antioxidants prevent health-promoting effects of physical exercise in humans

Michael Ristow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Ricki J. Colman et al.

SCIENCE (2009)

Article Multidisciplinary Sciences

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Colin Selman et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Yeast life span extension by depletion of 60S ribosomal subunits is mediated by Gcn4

Kristan K. Steffen et al.

Article Multidisciplinary Sciences

mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex

John T. Cunningham et al.

NATURE (2007)

Article Multidisciplinary Sciences

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C-elegans

Eric L. Greer et al.

CURRENT BIOLOGY (2007)

Article Cell Biology

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

Timothy M. Bass et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2007)

Article Multidisciplinary Sciences

Brain IRS2 signaling coordinates life span and nutrient homeostasis

Akiko Taguchi et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Ruth Scherz-Shouval et al.

EMBO JOURNAL (2007)

Article Medicine, General & Internal

Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

Anthony E. Civitarese et al.

PLOS MEDICINE (2007)

Review Medicine, General & Internal

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention - Systematic review and meta-analysis

Goran Bjelakovic et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)

Article Biochemistry & Molecular Biology

Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes

Gerd P. Bienert et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Resveratrol improves health and survival of mice on a high-calorie diet

Joseph A. Baur et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

Stefan M. Schieke et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Geriatrics & Gerontology

Calorie restriction in mice: Effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition

Sally C. Faulks et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2006)

Article Biochemistry & Molecular Biology

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

Florian L. Muller et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Article Multidisciplinary Sciences

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

Michael S. Bonkowski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

G López-Lluch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate

DR Valenzano et al.

CURRENT BIOLOGY (2006)

Article Cell Biology

Extension of chronological life span in yeast by decreased TOR pathway signaling

RW Powers et al.

GENES & DEVELOPMENT (2006)

Article Multidisciplinary Sciences

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

M Kaeberlein et al.

SCIENCE (2005)

Review Immunology

The anti-death machinery in IKK/NF-κB signaling

JL Luo et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2005)

Article Genetics & Heredity

Increased life span due to calorie restriction in respiratory-deficient yeast

M Kaeberlein et al.

PLOS GENETICS (2005)

Article Biochemistry & Molecular Biology

Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling

BM Emerling et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Cell Biology

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

JK Brunelle et al.

CELL METABOLISM (2005)

Article Biochemistry & Molecular Biology

Substrate-specific activation of sirtuins by resveratrol

M Kaeberlein et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Cell Biology

Overview of caloric restriction and ageing

EJ Masoro

MECHANISMS OF AGEING AND DEVELOPMENT (2005)

Article Multidisciplinary Sciences

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

L Fontana et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

JG Wood et al.

NATURE (2004)

Article Multidisciplinary Sciences

Premature ageing in mice expressing defective mitochondrial DNA polymerase

A Trifunovic et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

P Kapahi et al.

CURRENT BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans

OI Petriv et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

KT Howitz et al.

NATURE (2003)

Review Cell Biology

The chronological life span of Saccharomyces cerevisiae

P Fabrizio et al.

AGING CELL (2003)

Article Multidisciplinary Sciences

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

M Holzenberger et al.

NATURE (2003)

Article Geriatrics & Gerontology

Genetic mouse models of extended lifespan

HY Liang et al.

EXPERIMENTAL GERONTOLOGY (2003)

Article Geriatrics & Gerontology

No reduction of metabolic rate in food restricted Caenorhabditis elegans

K Houthoofd et al.

EXPERIMENTAL GERONTOLOGY (2002)

Article Multidisciplinary Sciences

Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction

B Rogina et al.

SCIENCE (2002)

Review Cell Biology

Control of cell survival by IGF signaling pathways

AM Vincent et al.

GROWTH HORMONE & IGF RESEARCH (2002)

Article Multidisciplinary Sciences

Dietary restriction in long-lived dwarf flies

DJ Clancy et al.

SCIENCE (2002)