Journal
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
Volume 131, Issue 3, Pages 265-268Publisher
WILEY
DOI: 10.1016/j.ijgo.2015.05.027
Keywords
Blood loss; Elective cesarean delivery; Tranexamic acid
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Objective: To study the efficacy and safety of preoperative intravenous tranexamic acid to reduce blood loss during and after elective lower-segment cesarean delivery. Methods: A single-blind, randomized placebo-controlled study was undertaken of women undergoing elective lower-segment cesarean delivery of a fullterm singleton pregnancy at a center in Cairo, Egypt, between November 2013 and November 2014. Patients were randomly assigned (1:1) using computer-generated random numbers to receive either 1 g tranexamic add or 5% glucose 15 minutes before surgery. Preoperative and postoperative complete blood count, hematocrit values, and maternal weight were used to calculate the estimated blood loss (EBL) during cesarean, which was the primary outcome. Analyses included women who received their assigned treatment, whose surgery was 90 minutes or less, and who completed follow-up. Results: Analyses included 100 women in each group. Mean EBL was significantly higher in the placebo group (700.3 +/- 143.9 mL) than in the tranexamic acid group (459.4 +/- 75.4 mL; P < 0.001). Only six women, all in the placebo group, experienced an EBL of more than 1000 mL There were no reports of thromboembolic events up to 4 weeks postoperatively. Conclusion: Preoperative administration of tranexamic acid safely reduces blood loss during elective lower-segment cesarean delivery. (C) 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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