Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 297, Issue 3, Pages E578-E591Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00093.2009
Keywords
adenosine 5 '-monophosphate-activated protein kinase; fatty acids; glucose; heart; insulin resistance; liver; mitochondria; peroxisome proliferator-activated receptor; skeletal muscle; type 2 diabetes
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Funding
- Belgian Fund for Medical Scientific Research
- Interuniversity Poles of Attraction Belgian Science Policy [P5/05]
- French Community of Belgium
- European Commission [LSHM-CT-2004-005272]
- National Institutes of Health of the US Public Health Service [RO1-HL-073162]
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Hue L, Taegtmeyer H. The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab 297: E578-E591, 2009. First published June 16, 2009; doi: 10.1152/ajpendo.00093.2009.-In 1963, Lancet published a paper by Randle et al. that proposed a glucose-fatty acid cycle to describe fuel flux between and fuel selection by tissues. The original biochemical mechanism explained the inhibition of glucose oxidation by fatty acids. Since then, the principle has been confirmed by many investigators. At the same time, many new mechanisms controlling the utilization of glucose and fatty acids have been discovered. Here, we review the known short- and long-term mechanisms involved in the control of glucose and fatty acid utilization at the cytoplasmic and mitochondrial level in mammalian muscle and liver under normal and pathophysiological conditions. They include allosteric control, reversible phosphorylation, and the expression of key enzymes. However, the complexity is formidable. We suggest that not all chapters of the Randle cycle have been written.
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