Journal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Volume 296, Issue 5, Pages C1207-C1217Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00511.2008
Keywords
eukaryotic initiation factor 4E; stress granules
Categories
Funding
- NCI NIH HHS [1-01-CA-114475] Funding Source: Medline
Ask authors/readers for more resources
Sukarieh R, Sonenberg N, Pelletier J. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. Am J Physiol Cell Physiol 296: C1207-C1217, 2009. First published February 25, 2009; doi:10.1152/ajpcell.00511.2008. Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate the SG localization of eIF4E.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available