Journal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Volume 295, Issue 3, Pages C761-C767Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00227.2008
Keywords
connexin; transport; erythrocyte; ATP release
Categories
Funding
- National Institutes of Health (NIH) [GM-48610]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM048610] Funding Source: NIH RePORTER
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Probenecid is a well-established drug for the treatment of gout and is thought to act on an organic anion transporter, thereby affecting uric acid excretion in the kidney by blocking urate reuptake. Probenecid also has been shown to affect ATP release, leading to the suggestion that ATP release involves an organic anion transporter. Other pharmacological evidence and the observation of dye uptake, however, suggest that the nonvesicular release of ATP is mediated by large membrane channels, with pannexin 1 being a prominent candidate. In the present study we show that probenecid inhibited currents mediated by pannexin 1 channels in the same concentration range as observed for inhibition of transport processes. Probenecid did not affect channels formed by connexins. Thus probenecid allows for discrimination between channels formed by connexins and pannexins.
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