Journal
NATURE REVIEWS CANCER
Volume 8, Issue 6, Pages 425-437Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2397
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Funding
- NCI NIH HHS [CA40355, P50 CA068438, R01 CA040355] Funding Source: Medline
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Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay between free radicals, hypoxia and HIF1 activity is complex and can influence the earliest stages of tumour development. The hypoxic environment of tumours is heterogeneous, both spatially and temporally, and can change in response to cytotoxic therapy. Free radicals created by hypoxia, hypoxia - reoxygenation cycling and immune cell infiltration after cytotoxic therapy strongly influence HIF1 activity. HIF1 can then promote endothelial and tumour cell survival. As discussed here, a constant theme emerges: inhibition of HIF1 activity will have therapeutic benefit.
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