Journal
NATURE REVIEWS CANCER
Volume 8, Issue 6, Pages 438-449Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2396
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [P30-CA01687, R37-CA76584, R21-CA125173] Funding Source: Medline
- NIGMS NIH HHS [R01 GM057587, R01 GM057587-11, R01-GM57587] Funding Source: Medline
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The maintenance and preservation of distinct phases during the cell cycle is a highly complex and coordinated process. It is regulated by phosphorylation - through the activity of cyclin-dependent kinases (CDKs) - and protein degradation, which occurs through ubiquitin ligases such as SCF (SKP1 - CUL1 - F-box protein) complexes and APC/C (anaphase-promoting complex/cyclosome). Here, we explore the functionality and biology of the F-box proteins, SKP2 (S-phase kinase-associated protein 2) and beta-TrCP (beta-transducin repeat-containing protein), which are emerging as important players in cancer biogenesis owing to the deregulated proteolysis of their substrates.
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