Journal
JOURNAL OF MATHEMATICAL BIOLOGY
Volume 56, Issue 6, Pages 793-825Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00285-007-0139-x
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Funding
- NINDS NIH HHS [R01 NS042645, R01 NS042645-05] Funding Source: Medline
- Direct For Computer & Info Scie & Enginr
- Division Of Computer and Network Systems [0929947] Funding Source: National Science Foundation
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We present a framework for modeling gliomas growth and their mechanical impact on the surrounding brain tissue (the so-called, mass-effect). We employ an Eulerian continuum approach that results in a strongly coupled system of nonlinear Partial Differential Equations (PDEs): a reaction-diffusion model for the tumor growth and a piecewise linearly elastic material for the background tissue. To estimate unknown model parameters and enable patient-specific simulations we formulate and solve a PDE-constrained optimization problem. Our two main goals are the following: (1) to improve the deformable registration from images of brain tumor patients to a common stereotactic space, thereby assisting in the construction of statistical anatomical atlases; and (2) to develop predictive capabilities for glioma growth, after the model parameters are estimated for a given patient. To our knowledge, this is the first attempt in the literature to introduce an adjoint-based, PDE-constrained optimization formulation in the context of image-driven modeling spatio-temporal tumor evolution. In this paper, we present the formulation, and the solution method and we conduct 1D numerical experiments for preliminary evaluation of the overall formulation/methodology.
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