Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 184, Issue 8, Pages 2342-2354Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2014.04.011
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Funding
- NIH [R01-CA121115]
- American Cancer Society
- Department of Pathology
- NIH Cancer Center Support Grant [P30-CA014520-39]
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Thyroid carcinoma is the most common endocrine malignancy, and papillary thyroid carcinoma represents the most common thyroid cancer. Papillary thyroid carcinomas that invade locally or metastasize are associated with a poor prognosis. We found that, during epithelial-mesenchymal transition (EMT) induced by transforming growth factor-beta 1 (TGF-beta 1), papillary thyroid carcinoma cells acquired increased cancer stem cell-Like features and the transcription factor paired-related homeobox protein 1 (PRRX1; alias PRX-1), a newly identified EMT inducer, was markedly up-regulated. miR-146b-5p was also transiently up-regulated during EMT, and in siRNA experiments miR-146b-5p had an inhibitory role on cell proliferation and invasion during TGF-beta 1-induced EMT. We conclude that papillary thyroid carcinoma tumor cells exhibit increased cancer stem cell-Like features during TGF-beta 1-induced EMT, that miR-146b-5p has a rote in cell proliferation and invasion, and that PRRX1 plays an important role in papillary thyroid carcinoma EMT and disease progression.
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