Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 180, Issue 5, Pages 1897-1905Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2012.01.018
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Funding
- UK Multiple Sclerosis Society
- Swiss National Science Foundation [PP00P3_128372/1]
- MRC [G0800784] Funding Source: UKRI
- Swiss National Science Foundation (SNF) [PP00P3_128372] Funding Source: Swiss National Science Foundation (SNF)
- Medical Research Council [G0800784B, G0800784] Funding Source: researchfish
- Rosetrees Trust [M144] Funding Source: researchfish
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In addition to being an established risk factor for neurodegenerative diseases, age is increasingly recognized as adversely influencing regeneration. Accumulating evidence also suggests that age plays important, although poorly understood, roles with respect to course and prognosis in the degenerative and untreatable later phase of multiple sclerosis. Two experimental models of multiple sclerosis have been particularly influential in modeling the different aspects of neuronal injury and regeneration: global experimental autoimmune encephalomyelitis and focal toxin-mediated injury. Against this background, we report a focal model of immune-mediated demyelinating injury that reliably generates targeted primary demyelination and axonal injury. A detailed pathologic characterization of this model, modified extensively from an earlier study, showed that aged adult animals exhibited increased vulnerability to axonal injury and reduced efficiency of remyelination compared with younger animals. More important, remyelination in aged animals was predominantly Schwann cell mediated, in contrast to the central oligodendrocyte-mediated remyelination that predominated in younger rodents. Together, these findings establish an experimental platform to further study the influence of age on injury and repair in a biologically relevant model of human demyelinating injury. (Am J Pathol 2012, 180: 1897-1905; DOI: 10.1016/j.ajpath.2012.01.018)
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