Single high-dose vitamin D at birth corrects vitamin D deficiency in infants in Mexico

This study examined the prevalence of vitamin D deficiency in mothers and infants in Tijuana, Mexico and determined the effect of a single oral dose of 50 000 IU vitamin D-3 at birth on 25-hydroxyvitamin D (25[OH] D) levels during infancy. Healthy infants were randomized to receive vitamin D-3 or placebo at birth. At birth 23% of infants were vitamin D deficient and 77% had vitamin D insufficiency (mean 25[OH] D level 18.9 ng/ml); 10% of mothers were vitamin D deficient and 61% were insufficient. Infants receiving vitamin D-3 had higher 25(OH) D levels at two months (N = 29; 33.9 versus 24.2 ng/ml) and six months (N = 21; 36.5 versus 27.4 ng/ml). Exclusively breastfed infants had lower 25(OH) D levels at two months (14.9 versus 33.4 ng/ml). Vitamin D deficiency is common in infants and mothers in Tijuana, Mexico. A single dose of vitamin D-3 at birth was safe and significantly increased 25(OH) D levels during infancy.