Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 7, Pages 512-522Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2318
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Funding
- NCRR NIH HHS [K01 RR000163, P51 RR000163, RR 0163] Funding Source: Medline
- NIAID NIH HHS [N01AI50027] Funding Source: Medline
- NIA NIH HHS [AG23664, AG20719, P01 AG023664, AG21384, U01 AG021384, R01 AG020719, R37 AG020719] Funding Source: Medline
- PHS HHS [N0150027] Funding Source: Medline
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A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.
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