Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 7, Pages 495-500Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2338
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The activation of T cells is vital to the successful elimination of pathogens, but can also have a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are triggered by the T-cell receptor; these have key roles in the control of the T-cell response and represent interesting targets for therapeutic immunomodulation. Recent findings define MALT1 ( mucosa associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell-receptor-induced signalling pathways.
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