Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 206, Issue 4, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2011.12.029
Keywords
benign gynecological disease; biomarker; CA125; HE4; healthy women
Categories
Funding
- National Cancer Institute [NCI 1 R01 CA136491-01]
- Fujirebio Diagnostics Inc
- Abbott Diagnostics Inc.
- Beckman Coulter Inc
- National Cancer Institute's Early Detection Research Network [U01-CA152990]
- M. D. Anderson Cancer Center Ovarian SPORE [CA83639]
- Fujirebio Diagnostics Inc [CA125]
- Scientific Advisory Boards of Vermillion Inc
- Illumina Inc.
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OBJECTIVE: The human epididymis protein 4 (HE4) is a novel biomarker for ovarian cancer. This study measured the HE4 and CA125 levels in women with benign gynecological disorders. STUDY DESIGN: Sera were obtained from women prior to surgery for a pelvic mass and HE4 and CA125 levels were determined. The proportions of patients with elevated biomarker levels were compared. RESULTS: There were 1042 women with benign disease. HE4 levels were less often elevated than CA125 (8% vs 29%, P < .001). A marked difference was observed in patients with endometriosis in which HE4 was elevated in 3% of patients and CA125 in 67% (P < .0001). Serous ovarian tumors were associated with elevated levels of HE4 in 8% of patients and CA125 in 20% (P < .0002); uterine fibroids in 8% vs 26% (P < .0083); dermoids in 1% vs 21% (P < .0004); and inflammatory disease in 10% vs 37% (P < .014). CONCLUSION: HE4 is elevated less frequently than CA125 in benign disease, particularly in premenopausal patients.
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