Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 205, Issue 6, Pages 518-525Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2011.05.042
Keywords
endometrial cancer; estrogen; insulin; obesity; prevention
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Funding
- NCI NIH HHS [P30 CA016672, P50 CA098258] Funding Source: Medline
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Worldwide, obesity has become a major public health crisis. Overweight and obesity not only increase the risk of cardiovascular disease and type-2 diabetes mellitus but also are now known risk factors for a variety of cancer types. Among all cancers, increasing body mass index is associated most strongly with endometrial cancer incidence and death. The molecular mechanisms underlying how adipose tissue and obesity contribute to the pathogenesis of endometrial cancer are becoming better understood and have revealed a number of rational strategies, both behavioral and pharmaceutical, for the prevention of both primary and recurrent disease.
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