Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 204, Issue 1, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2010.08.043
Keywords
decidua; genomewide gene expression; microarray; preeclampsia
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Funding
- Norwegian University of Science and Technology
- Central Norway Regional Health Authority
- Research Council of Norway
- Fulbright Foundation for Educational Exchange
- National Institutes of Health [R01 HD049847, R01 MH059490]
- Southwest Foundation Forum
- National Center for Research Resources, National Institutes of Health [C06 RR017515]
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OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks. RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were over-represented canonical pathways. CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved.
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