Journal
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
Volume 195, Issue -, Pages 30-39Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijfoodmicro.2014.11.028
Keywords
Biofilm formation; Cinnamon bark oil; Cinnamaldehyde; Eugenol; Hemolysis; Toxin production
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education [2014R1A6A1031189]
- National Research Foundation of Korea [2014R1A6A1031189] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The long-term usage of antibiotics has resulted in the evolution of multidrug resistant bacteria, and pathogenic biofilms contribute to reduced susceptibility to antibiotics. In this study, 83 essential oils were initially screened for biofilm inhibition against Pseudomonas aeruginosa. Cinnamon bark oil and its main constituent cinnamaldehyde at 0.05% (v/v) markedly inhibited P. aeruginosa bioffim formation. Furthermore, cinnamon bark oil and eugenol decreased the production of pyocyanin and 2-hepty1-3-hydroxy-4(1H)-quinolone, the swarming motility, and the hemolytic activity of P. aeruginosa. Also, cinnamon bark oil, cinnamaldehyde, and eugenol at 0.01% (v/v) significantly decreased biofilm formation of enterohemorrhagic Escherichia colt 0157: H7 (EHEC). Transcriptional analysis showed that cinnamon bark oil down-regulated curli genes and Shiga-like toxin gene stx2 in EHEC. In addition, biodegradable poly(lactic-co-glycolic acid) film incorporating biofilm inhibitors was fabricated and shown to provide efficient biofilm control on solid surfaces. This is the first report that cinnamon bark oil and its components, cinnamaldehyde and eugenol, reduce the production of pyocyanin and PQS, the swarming motility, and the hemolytic activity of P. aeruginosa, and inhibit EHEC biofilm formation. (c) 2014 Elsevier B.V. All rights reserved.
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