Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 205, Issue 1, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2011.02.059
Keywords
age; menopause; natural menopause; onset; risk factors; surgical menopause
Categories
Funding
- Wyeth-Ayerst International Inc, Madison, NJ
- Royal College of General Practitioners
- Medical Research Council
- Cancer Research UK
- British Heart Foundation
- Cruden Foundation
- Chief Scientist Office Scotland
- Schering AG
- Schering Health Care Ltd
- Ortho Cilag
- Searle
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OBJECTIVE: We sought to describe the pattern of age at menopause and factors associated with type of menopause. STUDY DESIGN: This was a prospective cohort study of 5113 postmenopausal health survey respondents in the Royal College of General Practitioners' Oral Contraception Study. Logistic regression was used to evaluate associations between sociodemographics, lifestyle, and medical history and menopause type. RESULTS: Median age at natural menopause (n = 3650) was 49.0 years (interquartile range, 45.0-51.0), and at surgical menopause (n = 1463) was 42.4 years (38.0-46.4). Early natural menopause was associated with smoking, ever-use of oral contraception, sterilization, and history of endometriosis (all increased odds ratios) and ever-use of hormone replacement therapy (decreased). Surgical menopause was associated with manual social class, sterilization, and having a history of endometriosis, menorrhagia, or painful menstruation (all increased), and ever-use of hormone replacement therapy (decreased). CONCLUSION: Age at natural menopause was younger in this cohort than in other studies. More associations were found for surgical menopause than early natural menopause.
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