Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 202, Issue 5, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2010.02.034
Keywords
effector; initiator; labor; myometrium; preterm birth
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Funding
- NHLBI NIH HHS [R01HL049041-12, R01 HL049041-12, R01 HL049041] Funding Source: Medline
- NCCDPHP CDC HHS [U01 DP000187-02, U01 DP000187] Funding Source: Medline
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OBJECTIVE: Distinct processes govern transition from quiescence to activation during term (TL) and preterm labor (PTL). We sought gene sets that are responsible for TL and PTL, along with the effector genes that are necessary for labor independent of gestation and underlying trigger. STUDY DESIGN: Expression was analyzed in term and preterm with or without labor (n = 6 subjects/ group). Gene sets were generated with logic operations. RESULTS: Thirty-four genes were expressed similarly in PTL/TL but were absent from nonlabor samples (effector set); 49 genes were specific to PTL (preterm initiator set), and 174 genes were specific to TL (term initiator set). The gene ontogeny processes that comprise term initiator and effector sets were diverse, although inflammation was represented in 4 of the top 10; inflammation dominated the preterm initiator set. CONCLUSION: TL and PTL differ dramatically in initiator profiles. Although inflammation is part of the term initiator and the effector sets, it is an overwhelming part of PTL that is associated with intraamniotic inflammation.
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