Journal
HUMAN BRAIN MAPPING
Volume 29, Issue 8, Pages 958-972Publisher
WILEY-LISS
DOI: 10.1002/hbm.20440
Keywords
test-retest; reproducibility; intraclass correlation coefficient; multicenter; fMRI
Funding
- NCRR NIH HHS [U24 RR021992, U24 RR021992-01A1, 1 U24 RR021992] Funding Source: Medline
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In the present report, estimates of test-retest and between-site reliability of fMRI assessments were produced in the context of a multicenter fMRI reliability study (FBIRN Phase 1, www.nbirn.net). Five subjects were scanned on 10 MRI scanners on two occasions. The fMRI task was a simple block design sensorimotor task. The impulse response functions to the stimulation block were derived using an FIR-cleconvolution analysis with FMRISTAT. Six functionally-derived ROls covering the visual, auditory and motor cortices, created from a prior analysis, were used. Two dependent variables were compared: percent signal change and contrast-to-noise-ratio. Reliability was assessed with intraclass correlation coefficients derived from a variance components analysis. Test-retest reliability was high, but initially, between-site reliability was low, indicating a strong contribution from site and site-by-subject variance. However, a number of factors that can markedly improve between-site reliability were uncovered, including increasing the size of the ROls, adjusting for smoothness differences, and inclusion of additional runs. By employing multiple steps, between-site reliability for 3T scanners was increased by 123%. Dropping one site at a time and assessing reliability can be a useful method of assessing the sensitivity of the results to particular sites. These findings should provide guidance to others on the best practices for future multicenter studies.
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