Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 200, Issue 5, Pages E60-E62Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2008.10.012
Keywords
cardiovascular disease; hypertension; preeclampsia; pregnancy; pregnancy complications
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OBJECTIVE: Women with a history of preeclampsia are at increased risk for long-term cardiovascular morbidity and mortality. This study assessed whether a pregnancy complicated by preeclampsia is associated with an increased prevalence of maternal hypertension and other cardiovascular risk factors shortly after delivery. STUDY DESIGN: Seventy-nine cases and 140 controls that had been enrolled in a prospective case-control study were evaluated in this planned follow-up analysis. The presence of hypertension, diabetes and dyslipidemia were assessed by standardized questionnaire 6-13 months after delivery. RESULTS: Women with preeclampsia were significantly more likely than controls to have hypertension (adjusted odds ratio, 13.92; 95% CI, 5.17-37.4; P < .001) after adjusting for confounders. Women with preterm preeclampsia also had an increased odds of hypertension (adjusted odds ratio, 18.31; 95% CI, 5.04-66.46; P < .001) compared with controls. CONCLUSION: Pregnancy complications, such as preeclampsia, may provide opportunities to identify women at risk for cardiovascular morbidity years before the onset of disease, allowing a window for prevention and intervention.
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