Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 200, Issue 3, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2008.12.052
Keywords
body fat; body weight; depot medroxyprogesterone acetate; oral contraception
Categories
Funding
- NCRR NIH HHS [M01RR000073, M01 RR000073-438696, M01 RR000073-447287, M01 RR000073, M01 RR000073-41S10528, M01 RR000073-455386, M01 RR000073-42A10528] Funding Source: Medline
- NICHD NIH HHS [K24 HD043659-04, K24 HD043659-05, R01 HD039883-05, R01 HD039883-02S1, R01 HD039883-02, K24 HD043659-01, R01 HD039883, K24 HD043659-02, R01 HD039883-01A1, R01 HD039883-03, K24 HD043659-06, R01HD39883, K24 HD043659, R01 HD039883-04, K24 HD043659-03, K24HD043659] Funding Source: Medline
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OBJECTIVE: The purpose of this study was to determine changes in bodyweight and composition that result from hormonal contraception. STUDY DESIGN: Dual-energy x-ray absorptiometry was performed at baseline and every 6 months for 3 years for 703 women (African American, 200; white, 247; Hispanic, 256) who were beginning the use of oral contraception (OC; n = 245), depot medroxyprogesterone acetate (DMPA; n = 240), or nonhormonal contraception (NH; n = 218). DMPA discontinuers were observed for up to 2 years to examine the reversibility of the observed changes. RESULTS: Over 36 months, DMPA users increased their weight (+5.1 kg), body fat (+4.1 kg), percent body fat (+3.4%), and central-to-peripheral fat ratio (+0.1) more than OC and NH users (P < .01). OC use did not cause weight gain. After DMPA discontinuation, NH users lost 0.42 kg in 6 months; OC users gained 0.43 kg in 6 months. CONCLUSION: Bodyweight and fat significantly increase with the use of DMPA. After discontinuation of DMPA, some decrease in bodyweight and fat occurs when NH is used.
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