Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 8, Pages 644-654Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2377
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Funding
- NCRR NIH HHS [P51 RR000166, R24 RR016354, P51RR000166, R24RR016354] Funding Source: Medline
- NHLBI NIH HHS [R01HL080621, R01 HL080621] Funding Source: Medline
- NIAID NIH HHS [R21AI017892, P01 AI058113, R01AI022646, R01 AI017892, P01 AI052106, R01 AI022646, P01AI052106, P01AI058113] Funding Source: Medline
- NIDA NIH HHS [P30DA015625, P30 DA015625] Funding Source: Medline
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Although often encoding fewer than a dozen genes, RNA viruses can overcome host antiviral responses and wreak havoc on the cells they infect. Some manage to evade host antiviral defences, whereas others elicit an aberrant or disproportional immune response. Both scenarios can result in the disruption of intracellular signalling pathways and significant pathology in the host. Systems-biology approaches are increasingly being used to study the processes of viral triggering and regulation of host immune responses. By providing a global and integrated view of cellular events, these approaches are beginning to unravel some of the complexities of virus-host interactions and provide new insights into how RNA viruses cause disease.
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