Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 199, Issue 6, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2008.06.090
Keywords
cerebral palsy; intrauterine inflammation; microglia; perinatal brain injury
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Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K08HD050652] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
- NICHD NIH HHS [K08 HD050652-02, K08 HD050652-03, K08 HD050652] Funding Source: Medline
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OBJECTIVE: This study was undertaken to determine whether maternal intrauterine endotoxin administration leads to neurobehavioral deficits in newborn rabbits. STUDY DESIGN: Pregnant New Zealand white rabbits were injected with 1 mL saline solution ( n = 8) or 20 mu g/kg of lipopolysaccharide in saline solution ( n = 8) into the uterine wall on day 28/31 of gestation. On postnatal day 1, kits ( saline solution [ n = 30] and lipolysaccharide in saline solution [ n = 18] from 4 consecutive litters) underwent neurobehavioral testing. Neonatal brains were stained for microglial cells and myelin. RESULTS: Kits in the lipopolysaccharide in saline solution group were hypertonic and demonstrated significant impairment in posture, righting reflex, locomotion, and feeding, along with neuroinflammation indicated by activated microglia and hypomyelination in the periventricular regions. A greater mortality was noted in the lipopolysaccharide in saline solution group ( 16 stillbirths from 3 litters vs 3 from 1 litter). CONCLUSION: Maternal intrauterine endotoxin administration leads to white matter injury and motor deficits in the newborn rabbit, resulting in a phenotype that resembles those found in periventricular leukomalacia and cerebral palsy.
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