Journal
EUROPEAN JOURNAL OF PEDIATRICS
Volume 167, Issue 8, Pages 885-890Publisher
SPRINGER
DOI: 10.1007/s00431-007-0612-y
Keywords
pediatric nephrology; solitary kidney; renal function; progression; multicystic kidney disease
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In patients with a single functioning kidney, renal function was assessed at regular intervals over a period of 10 years. Serum creatinine, glomerular filtration rate (GFR), blood pressure, and urinary protein-creatinine ratio were assessed at the age of 2, 5 and 10 years. Between January 1980 and December 2005, 99 such patients were diagnosed in the first year of life. They were divided into three groups: A, patients with multicystic kidney disease and a normal contralateral kidney (n=36); B, patients with a normal solitary kidney without uropathy (n=20); and C, patients with obstructive uropathy and one nonfunctioning kidney (n=43). Serum creatinine levels increased significantly with increasing age in every group. In group C, serum creatinine was significantly elevated compared with group A in all age categories (p=0.043, p=0.019, p=0.001 respectively). Median figures of GFR remained within normal limits over the 10-year period. GFR was significantly lower in group C compared with group A (p=0.001, p=0.009, p=0.019 respectively) and B in all age categories (p=0.013, p=0.002, p=0.016 respectively). There were no changes in blood pressure over time and no differences among the three groups were observed. At the age of 10 years, the patients in group C had a significantly higher median urinary protein-creatinine ratio (p=0.022) than those in groups A and B. There was also an increasing level of proteinuria with increasing age in group C (p=0.002). In conclusion, renal function was stable over time in all patients, but children with obstructive uropathy have a lower median GFR and higher serum creatinine level for the whole study period. Hypertension was exceptionally observed in group C, with obstructive uropathy, as was an elevated urinary protein-creatinine ratio.
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