Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 53, Issue 8, Pages 2053-2058Publisher
SPRINGER
DOI: 10.1007/s10620-007-0131-8
Keywords
Helicobacter pylori; stool antigen test; immunoassay; immunochromatography; children
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The rapid immunochromatography for Helicobacter pylori (H. pylori) stool antigen (rapid HpSA) test is a recently-developed method for detection of H. pylori infection. The objective of this study was to assess the pre and post-eradication diagnostic accuracy of the rapid HpSA test compared with the conventional HpSA immunoassay (HpSA ELISA) in children. Sensitivity, specificity, positive predictive value, and negative predictive value for the rapid HpSA test were 94.6, 98.4, 94.6, and 98.4%, respectively, and those for the HpSA ELISA were 94.6, 96.1, 87.5, and 98.4%, respectively. No significant difference was observed between the sensitivity and specificity of the two HpSA tests in children (P = 1.000 and P = 0.250) or the sensitivity and specificity of the two HpSA tests pre and post-eradication therapy (P = 1.000 and P = 1.000). The rapid HpSA and HpSA ELISA are reliable methods of detection of H. pylori infection in the pediatric population before and after eradication therapy.
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