Journal
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Volume 45, Issue 6, Pages 1927-1937Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyv074
Keywords
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Categories
Funding
- Marie Curie Intra-European Fellowship for Career Development [FP7PEOPLE-2010-IEF-273673]
- UCL Hospitals NIHR Biomedical Research Centre
- VENI [91612122]
- Ipse Movet
- Medical Research Council [MC_UU_12013/1, MC_UU_12013/5, MC_UU_12013/8]
- Medical Research Council Population Health Scientist Fellowship [G0802432]
- British Heart Foundation (BHF)
- UK Medical Research Council
- Department of Health (England)
- Institute of Alcohol Studies
- Stroke Association
- BUPA Foundation
- Wellcome Trust
- National Institute for Health Research School of Primary Care Research
- BHF Senior Fellowship
- British Heart Foundation
- Department of Health Policy Research Programme (England)
- BHF [PG/07/131/24254]
- Medical Research Council of the UK [G0500877, G0902037, ID85374]
- National Heart, Lung, and Blood Institute (NHLBI) [HHSN268200960009C, N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01HC-55020, N01-HC-55021, N01-HC-55022, N01-HC-95159, N01-HC-95169, RR-024156]
- British Heart Foundation [PG/07/131/24254, RG/98002, CH/98001, RG/07/005/23633, RG/10/12/28456, RG/07/008/23674]
- Chief Scientist Office of Scotland [CZB/4/672]
- National Institute on Aging in the US [R01AG017644, R01AG1764406S1]
- UK Government
- Department for Communities and Local Government
- Department for Transport
- Department for Work and Pensions
- Department of Health
- HM Revenue and Customs
- Office for National Statistics
- 'Europe against Cancer' Programme of the European Commission (SANCO)
- Dutch Ministry of Public Health, Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- LK Research Funds
- Dutch Prevention Funds
- Dutch Cancer Society
- ZonMW
- Netherlands Organisation for Health Research and Development and World Cancer Research Fund (WCRF) (The Netherlands)
- IOP Genomics from Agentschap NL [IGE05012]
- Chief Scientist Office of Scottish [CZQ/1/38]
- Pfizer plc (Unrestricted Investigator Led Grant)
- Diabetes UK (Clinical Research Fellowship) [10/0003985]
- 7th Framework Program (integrated project AtheroRemo) of the European Union [201668]
- 7th Framework Program (RiskyCAD) of the European Union [305739]
- INTERREG IV Oberrhein Program, European Regional Development Fund (ERDF) [A28]
- Wissenschaftsoffensive TMO
- Pharmacia
- European Union Ingenious HyperCare Consortium: Integrated Genomics, Clinical Research, and Care in Hypertension [LSHM-C7-2006-037093]
- EC Sixth Framework Programme [LSHM-CT-2007-037273]
- BHF Centre for Research Excellence
- Wellcome Trust core award [090532/Z/09/Z]
- MRC
- Swedish Heart-Lung Foundation
- Swedish Medical Research Council [8691]
- Knut and Alice Wallenberg Foundation
- Karolinska Institute and the Stockholm County Council [560183]
- National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services [N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, 44221]
- National Heart Lung and Blood Institute [5RO1 HL036310]
- National Institute on Aging [5RO1AG13196]
- Agency for Health Care Policy Research [HS06516]
- John D. and Catherine T. MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health
- ESRC [ES/J023299/1] Funding Source: UKRI
- MRC [MC_UU_12013/8, MR/N01104X/1, G0902037, G0802432, MC_UU_12019/1, MC_PC_U127561128, MC_UU_12013/1, MR/K013351/1, MR/K006215/1, G1001799, G0500877, MC_UU_12013/5] Funding Source: UKRI
- British Heart Foundation [RG/13/16/30528, PG/13/66/30442, RG/07/008/23674, RG/08/008/25291, RG/08/013/25942, RG/10/12/28456] Funding Source: researchfish
- Chief Scientist Office [CZB/4/710, CZB/4/672] Funding Source: researchfish
- Economic and Social Research Council [ES/J023299/1] Funding Source: researchfish
- Medical Research Council [G0500877, MR/N01104X/1, MC_UU_12013/8, MC_UU_12013/1, MR/K013351/1, G0802432, MR/K006215/1, MC_UU_12013/5, G0902037, MC_UU_12019/1, MC_PC_U127561128, G1001799] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0515-10091] Funding Source: researchfish
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Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis. Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D. Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively], which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P<0.001), triglycerides (P<0.001), non high-density (non-HDL) cholesterol (P<0.001), C-reactive protein (P = 0.042), and systolic blood pressure (P = 0.064) and higher levels of forced expiratory volume in 1 s and forced vital capacity (P<0.001 for both). Conclusions: Taller individuals have a lower risk of CHD with potential explanations being that taller people have a better lung function and lower levels of body mass index, cholesterol and blood pressure.
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