Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 104, Issue 6, Pages 1988-1993Publisher
WILEY
DOI: 10.1002/jcb.21363
Keywords
nuclear matrix; nuclear structure; tumor markers; biomarkers
Categories
Funding
- NCI NIH HHS [R29 CA065463, R29 CA065463-04, CA65463, U01 CA084968-01, CA084968, U01 CA084968] Funding Source: Medline
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There are few biomarkers that have been developed which have proven clinical utility for the detection and prognosis of cancer. Cancer is diagnosed today, in large part, by examining cells under the microscope and determining the shape and texture of the nucleus. The molecular underpinnings of this hallmark of cancer are the components of the nuclear matrix. Utilizing proteomics focused on this subset of proteins, biomarkers have been identified that are specific for cancer types including prostate, colon and bladder cancer. These cancer biomarkers now serve as the basis of assays which can specifically identify individuals with cancer by sampling their blood and/or urine. In addition, these may serve as potential therapeutic targeting or imaging approaches.
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