Journal
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Volume 44, Issue 4, Pages 1148-1160Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyv026
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Funding
- Murdoch Childrens Research Institute
- Barwon Health
- Deakin University
- National Health and Medical Research Council of Australia [607370, 1009044, 102997, 1082037, 1076667, 1084017]
- Jack Brockhoff Foundation
- Scobie Trust
- Shane O'Brien Memorial Asthma Foundation
- Our Women's Our Children's Fundraising Committee Barwon Health
- Rotary Club of Geelong
- Shepherd Foundation
- Victorian Government
- Ilhan Foundation
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The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [peter.vuillermin@deakin.edu.au].
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