Journal
AMERICAN JOURNAL OF NEURORADIOLOGY
Volume 32, Issue 8, Pages 1399-1407Publisher
AMER SOC NEURORADIOLOGY
DOI: 10.3174/ajnr.A2548
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Funding
- NIH (coinvestigator National Institute of Neurological Disorders and Stroke) [R01 NS43924, R01 EB002873, 1R01NS064592-01A1]
- Toshiba Medical Systems Corporation
- Toshiba
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BACKGROUND AND PURPOSE: The self-expanding V-POD is a second-generation flow-diverting device with a low-porosity PTFE patch on a self-expanding microstent. The authors evaluated this device for the treatment of elastase-induced aneurysms in rabbits. MATERIALS AND METHODS: Three V-POD types (A, circumferential patch closed-cell stent [n = 9]; B, asymmetric patch closed-cell stent In = 71; and C, asymmetric patch open-cell stent In = 411 were evaluated by using angiography, conebeam micro-CT, histology, and SEM. Aneurysm flow modifications were expressed in terms of immediate poststent/prestent ratios of maximum CA volume entering the aneurysm dome tracked on procedural angiograms. Flow modifications were correlated with 4 weeks' follow-up angiographic, micro-CT, histologic, and SEM results. RESULTS: Mechanical stent-deployment difficulties in 4 aneurysms (1 type A; 3 type B) led to suboptimal results and exclusion from analysis. Of the remaining 16 aneurysms, 4-week post-treatment angiograms showed no aneurysm filling in 10 (63%), 3 (similar to 19%) had no filling with a small remnant neck, and 3 (similar to 19%) had <0.25 filling. Successfully treated aneurysms (n = 16) demonstrated an immediate poststent/prestent CA maximum volume ratio of 0.13 +/- 0.18% (0.0%-0.5%). Favorable contrast-flow modification on immediate angiography after deployment correlated significantly with aneurysm occlusion on follow-up angiography, micro-CT, and histology. The occlusion percentage derived from micro-CT was 96 +/- 6.8%. Histology indicated advanced healing (grade 3) in the aneurysm dome in 13 of 16 cases. SEM revealed 15 of 16 stents in an advanced state of endothelialization. CONCLUSIONS: This study showed the feasibility and effectiveness of V-POD for aneurysm healing in a rabbit elastase model.
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