Journal
AMERICAN JOURNAL OF NEURORADIOLOGY
Volume 29, Issue 7, Pages 1228-1234Publisher
AMER SOC NEURORADIOLOGY
DOI: 10.3174/ajnr.A1030
Keywords
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Funding
- Human Brain Project
- National Institute of Biomedical Imaging and Bioengineering [EB004673, EB004573-02S2, EB003880]
- University School of Medicine
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The routine use of arterial spin-labeling (ASL) in a clinical population has led to the depiction of diverse brain pathologic features. Unique challenges in the acquisition, postprocessing, and analysis of cerebral blood flow (CBF) maps are encountered in such a population, and high-quality ASL CBF maps can be generated consistently with attention to quality control and with the use of a dedicated postprocessing pipeline. Familiarity with commonly encountered artifacts can help avoid pitfalls in the interpretation of CBF maps. The purpose of this review was to describe our experience with a heterogeneous collection of ASL perfusion cases with an emphasis on methodology and common artifacts encountered with the technique. In a period of I year, more than 3000 pulsed ASL cases were performed as a component of routine clinical brain MR evaluation at both 1.5 and 3T. These ASL studies were analyzed with respect to overall image quality and patterns of perfusion on final gray-scale DICOM images and color Joint Photographic Experts Group (JPEG) CBF maps, and common artifacts and their impact on final image quality were categorized.
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