Journal
AMERICAN JOURNAL OF NEPHROLOGY
Volume 40, Issue 6, Pages 582-591Publisher
KARGER
DOI: 10.1159/000371498
Keywords
Plant-based protein; Mineral; Phosphorus; Phytate
Categories
Funding
- Norman Coplon grant from the Satellite Health Care Foundation
- CRC/CTSI Clinical Research Center (CRC) [UL1TR001108]
- Indiana Clinical and Translational Sciences Institute - NIH [UL1TR001108, RR02576]
- NIH [AR058005]
- VA Merit Award
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR002529, UL1TR001108] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [KL2RR025760] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR058005] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Background: Chronic Kidney Disease (CKD) is associated with alterations in phosphorus excretion, and increases in fibroblast growth factor (FGF23) and parathyroid hormone (PTH). Plant protein-based phytate-bound phosphorus, is less bioavailable than that from animal sources. Our oneweek study that was conducted previously showed that a nearly 100% plant protein-based diet benefits mineral metabolism in CKD; however, this diet may not be acceptable to patients. Here we hypothesize that a diet containing 70% protein from plants has similar efficacy and is tolerated by CKD patients. Methods: Thirteen subjects with CKD 3-4 received an omnivorous diet containing 70% protein from plants for 4 weeks. The primary outcome was change in 24 h urine phosphorus. Secondary outcomes were changes in serum phosphorus, FGF23, PTH, urine sodium excretion, grip strength and fat free mass. Repeated measures analysis of variance (ANOVA) was used to test differences in parameters over the 4 weeks. Results: Mean age of subjects was 54.8 years. Median eGFR was 26 (IQR 14.7) ml/min/1.73 m(2). Over the 4-week period, urine phosphorus significantly decreased
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available