Journal
AMERICAN JOURNAL OF NEPHROLOGY
Volume 36, Issue 2, Pages 162-167Publisher
KARGER
DOI: 10.1159/000341263
Keywords
Autosomal-dominant polycystic kidney disease; Kidney volume; Hyperfiltration; Renal blood flow
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Funding
- International Society of Nephrology
- Laboratory of Kidney Pathology, Charles Nicolle Hospital, Tunis, Tunisia [LR00SP01-Pr]
- Zell Family Foundation
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Autosonnal-dominant polycystic kidney disease (ADPKD) is the most common single cause of end-stage renal disease after diabetes, hypertension and glomerulonephritis. The clinical course of ADPKD is highly variable. Even with optimal care and therapy monitoring, currently the progression of ADPKD is slowed but not stopped. Newer treatments will no doubt become available in the future, but their side effect profiles will always need to be considered. Therefore, markers to distinguish ADPKD patients with a poor versus a good prognosis will be helpful. Several risk factors influencing kidney disease progression in ADPKD have been identified in the current era. The present review will discuss the spectrum of early markers of ADPKD renal disease progression. Specifically, the volume of total kidney, hypertension, glomerular hyperfiltration, renal blood flow, microalbuminuria, uric acid, and urinary molecular markers will be discussed. On this background, implications for the prevention and treatment of kidney disease progression in ADPKD are also discussed. Copyright (C) 2012 S. Karger AG, Basel
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