Journal
AMERICAN JOURNAL OF NEPHROLOGY
Volume 33, Issue 4, Pages 313-318Publisher
KARGER
DOI: 10.1159/000324846
Keywords
Advanced glycation end products; Aging; Chronic kidney disease; Endogenous secretory receptor for advanced glycation end products
Categories
Funding
- National Institute on Aging [R01 AG027012, R01 AG029148, R01 HL094507, 9164, 263, 821336, N.1-AG-1-1, N.1-AG-1-2111, N01-AG-5-0002]
- Italian Ministry of Health [ICS110.1/RF97.71]
- National Institute on Aging, National Institutes of Health
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL094507] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [N01AG012111, R01AG029148, ZIAAG000971, ZIAAG001050, R01AG027012] Funding Source: NIH RePORTER
- National Institute on Minority Health and Health Disparities [R01MD009164] Funding Source: NIH RePORTER
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Background/Aims: The relationship of circulating endogenous secretory receptor for advanced glycation end products (esRAGE) and chronic kidney disease (CKD) has not been well characterized. The aim of the study was to determine whether plasma esRAGE is associated with CKD and is predictive of developing CKD in older adults. Methods: The relationship between plasma esRAGE and CKD (more than stage 3 of the National Kidney Foundation classification; estimated glomerular filtration rate <60 ml/min/1.73 m(2)) and CKD over 6 years of follow-up was examined in a cross-sectional and prospective study design in 1,016 men and women, 6 65 years, in the InCHIANTI study, a population-based cohort study of aging in Tuscany, Italy. Results: At enrollment, 158 (15.5%) had CKD. Mean (SD) plasma esRAGE was 0.45 (0.24) ng/ml. Plasma esRAGE (ng/ml) was associated with CKD (odds ratio per 1 SD = 1.30; 95% CI 1.1-1.6; p < 0.005) in a multivariable logistic regression model, adjusting for potential confounders. Plasma esRAGE was an independent predictor of incident CKD over 6 years of follow-up (hazard ratio per 1 SD = 1.37; 95% CI 1.1-1.7; p < 0.008) in a multivariable Cox proportional hazards model, adjusting for potential confounders. Conclusions: Elevated plasma esRAGE is independently associated with CKD and is an independent predictor of incident CKD in older community-dwelling adults. Copyright (C) 2011 S. Karger AG, Basel
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