Journal
AMERICAN JOURNAL OF MEDICINE
Volume 127, Issue 5, Pages 379-384Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjmed.2014.01.011
Keywords
Clinical epidemiology; Study design; Study outcomes and endpoints
Categories
Funding
- National Institutes of Health [RO1 HL35434, 1U01HL105268]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000161]
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We provide an overview of the individual and combined clinical endpoints and patient-reported outcomes typically used in clinical trials and prospective epidemiological investigations. We discuss the strengths and limitations associated with the utilization of aggregated study endpoints and surrogate measures of important clinical endpoints and patient-centered outcomes. We hope that the points raised in this overview will lead to the collection of clinically rich, relevant, measurable, and cost-efficient study outcomes. (c) 2014 Elsevier Inc. All rights reserved.
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