Journal
AMERICAN JOURNAL OF MEDICINE
Volume 124, Issue 5, Pages 395-401Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjmed.2010.11.025
Keywords
American Diabetes Association; Diabetes complications; Diabetes mellitus; Diagnosis; Fasting plasma glucose; Glycohemoglobin; Hemoglobin A1C; Oral glucose tolerance test
Categories
Funding
- National Institutes of Health [DK32520]
- American Diabetes Association [7-08-RA-106]
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Until 2010, the diagnosis of diabetes mellitus was based solely on glucose concentration, but the American Diabetes Association (ADA) recommendations now include a new criterion: hemoglobin A1C >= 6.5%. Because this change may have significant implications for diabetes diagnosis, we conducted a comprehensive literature review including peer-reviewed articles not referenced in the ADA report. We conclude that A1C and plasma glucose tests are frequently discordant for diagnosing diabetes. A1C >= 6.5% identifies fewer individuals as having diabetes than glucose-based criteria. Convenience of A1C test might increase the number of patients diagnosed, but this is unproven. Diagnostic cut-points for both glucose and A1C are based on consensus judgments regarding optimal sensitivity and specificity for the complications of hyperglycemia. A1C may not accurately reflect levels of glycemia in some situations, but in comparison with glucose measurements, it has greater analytic stability and less temporal variability. When choosing a diagnostic test for diabetes, the limitations of each choice must be understood. Clinical judgment and consideration of patient preference are required to appropriately select among the diagnostic alternatives. (C) 2011 Elsevier Inc. All rights reserved. The American Journal of Medicine (2011) 124, 395-401
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