Journal
AMERICAN JOURNAL OF MEDICINE
Volume 123, Issue -, Pages S28-S37Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjmed.2009.12.007
Keywords
Exenatide; GIP; GLP-1; Incretin; Sitagliptin; Type 2 diabetes mellitus
Categories
Ask authors/readers for more resources
Incretin hormones are secreted in response to food ingestion and help manage glycemic control by regulating insulin and glucagon release, slowing gastric emptying g. and reducing caloric intake. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, secreted front the L-cells of the lower gut and K-cells of the intestines, respectively, are responsible for these incretin effects, which are reduced in patients with type 2 diabetes mellitus. Initially, the rapid degradation of either incretin by dipeptidyl peptidase-4 (DPP-4) complicated the development of viable therapeutics based on either hormone. However. the US Food and Drug Administration (FDA) has approved 2* incretin-based therapies in which their mechanisms of action augment or amplify the effects of naturally occurring GLP-1. Exenatide, a first-in-class GLP-1 receptor agonist, exhibits the same mechanisms of action as native GLP-1. Sitagliptin inhibits the DPP-4 enzyme, thus increasing the half-life of endogenous GLP-1. This review examines data front recent GLP-1 receptor agonist and DPP-4 inhibitor studies in patients with type 2 diabetes, as well as data on other incretin-based therapies in clinical development. (C) 2010 Published by Elsevier Inc. The American Journal of Medicine: (2010) 123, S28-S37
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available