Journal
AMERICAN JOURNAL OF MEDICINE
Volume 122, Issue 2, Pages 22-32Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjmed.2008.12.004
Keywords
Fractures; Atrial fibrillation; Renal safety; Bisphosphonate safety; Oversuppression; Healing
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In this review 4 experts consider the major safety concerns relating to bisphosphonate therapy for osteoporosis. Specific topics covered are skeletal safety (particularly with respect to atypical fractures and delayed healing), gastrointestinal intolerance, hypocalcemia, acute-phase (i.e., postdose) reactions, chronic musculoskeletal pain, renal safety, and cardiovascular safety (specifically, atrial fibrillation). (C) 2009 Published by Elsevier Inc. The American Journal of Medicine (2009) 122, S22-S32
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